Reaction Details |
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Target | NPC1-like intracellular cholesterol transporter 1 |
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Ligand | BDBM50371539 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_463744 (CHEMBL932102) |
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Ki | >50000±n/a nM |
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Citation | Pfefferkorn, JA; Larsen, SD; Van Huis, C; Sorenson, R; Barton, T; Winters, T; Auerbach, B; Wu, C; Wolfram, TJ; Cai, H; Welch, K; Esmaiel, N; Davis, J; Bousley, R; Olsen, K; Mueller, SB; Mertz, T Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption. Bioorg Med Chem Lett18:546-53 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NPC1-like intracellular cholesterol transporter 1 |
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Name: | NPC1-like intracellular cholesterol transporter 1 |
Synonyms: | NPCL1_RAT | Niemann-Pick C1-like protein 1 | Npc1l1 |
Type: | PROTEIN |
Mol. Mass.: | 146415.18 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_463744 |
Residue: | 1331 |
Sequence: | MAAAWLGWLLWALLLSAAQGELYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSNT
PARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNF
VSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFYQRSFAEKAYESCSQVRIPAA
ASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGKI
APCNESQGDDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPGWLALIIIFTAVFVLLSA
VLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSPHTILGRFFQNWGTRVASWPLTVLALSF
IVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSSY
KYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYNT
SLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLAL
SCMADYGAPVFPFLAVGGYQGTDYSEAEALIITFSLNNYPADDPRMAQAKLWEEAFLKEM
ESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRV
AVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLE
YQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAI
ILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPPKEKEGLLLRFFRKIYAPFL
LHRFIRPVVMLLFLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPV
YFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDW
LTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDP
PNIRCPKGGLAAYRTSVNLSSDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITAD
LRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGI
LNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLE
RAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLP
VVLSYLGPDVNQALVQEEKLASEAAVAPEPSCPQYPSPADADANVNYGFAPELAHGANAA
RSSLPKSDQKF
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BDBM50371539 |
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n/a |
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Name | BDBM50371539 |
Synonyms: | CHEMBL256849 |
Type | Small organic molecule |
Emp. Form. | C24H21F2NO4 |
Mol. Mass. | 425.4246 |
SMILES | O[C@H](CCc1ccccc1)[C@H]1OC(=O)N([C@@H]1c1cccc(F)c1O)c1cccc(F)c1 |
Structure |
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