| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aromatase |
|---|
| Ligand | BDBM50041326 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_475715 (CHEMBL934601) |
|---|
| IC50 | 2400±n/a nM |
|---|
| Citation |  Crisman, TJ; Bender, A; Milik, M; Jenkins, JL; Scheiber, J; Sukuru, SC; Fejzo, J; Hommel, U; Davies, JW; Glick, M "Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits. J Med Chem51:2481-91 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aromatase |
|---|
| Name: | Aromatase |
|---|
| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57888.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11511 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
|
|
|
|---|
| BDBM50041326 |
|---|
| n/a |
|---|
| Name | BDBM50041326 |
|---|
| Synonyms: | 4-((2,3-dihydro-1H-inden-2-yl)methyl)pyridine | 4-Indan-2-ylmethyl-pyridine | CHEMBL24593 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H15N |
|---|
| Mol. Mass. | 209.2863 |
|---|
| SMILES | C(C1Cc2ccccc2C1)c1ccncc1 |
|---|
| Structure | 
|
|---|
Search and Browse
