| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50376913 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_478823 (CHEMBL925710) |
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| Kd | 14.79±n/a nM |
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| Citation |  Cappelli, A; Nannicini, C; Gallelli, A; Giuliani, G; Valenti, S; Mohr, Gl; Anzini, M; Mennuni, L; Ferrari, F; Caselli, G; Giordani, A; Peris, W; Makovec, F; Giorgi, G; Vomero, S Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems. J Med Chem51:2137-46 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41009.15 |
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| Organism: | RABBIT |
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| Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
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| Residue: | 359 |
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| Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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| BDBM50376913 |
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| n/a |
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| Name | BDBM50376913 |
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| Synonyms: | CHEMBL259353 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23N7O |
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| Mol. Mass. | 425.4857 |
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| SMILES | CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)c2cccnc12 |
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| Structure | 
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