| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Ligand | BDBM50034820 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491124 (CHEMBL991892) |
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| Ki | >300±n/a nM |
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| Citation |  Harris, D; Clayton, T; Cook, J; Sahbaie, P; Halliwell, RF; Furtmüller, R; Huck, S; Sieghart, W; DeLorey, TM Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. J Med Chem51:3788-803 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Synonyms: | GABA A Alpha4Beta2Gamma2 | GABA A Alpha4Beta3Gamma2 | GABA A Alpha4Gamma2 | GABA A receptor alpha-4/beta-3/gamma-2 | GABA receptor alpha-4 subunit | GABA(A) receptor subunit alpha-4 | GABRA4 | GBRA4_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 61648.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | GABA A Alpha4Beta2Gamma2 0 HUMAN::P48169 |
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| Residue: | 554 |
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| Sequence: | MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD
NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN
NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP
MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT
GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT
TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ
EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES
SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG
SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV
YLSKDTMEKSESLM
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| BDBM50034820 |
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| n/a |
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| Name | BDBM50034820 |
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| Synonyms: | 8-Chloro-3-methoxymethyl-5-methyl-4,5-dihydro-2,5,10b-triaza-benzo[e]azulen-6-one | CHEMBL45346 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14ClN3O2 |
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| Mol. Mass. | 291.733 |
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| SMILES | COCc1ncn-2c1CN(C)C(=O)c1cc(Cl)ccc-21 |
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| Structure | 
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