Ki Summary

Reaction Details

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Target

Gamma-aminobutyric acid receptor subunit alpha-6

Ligand

BDBM50049736

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_491430 (CHEMBL948525)

EC50

51700±n/a nM

Citation

Harris, D; Clayton, T; Cook, J; Sahbaie, P; Halliwell, RF; Furtmüller, R; Huck, S; Sieghart, W; DeLorey, TM Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. J Med Chem51:3788-803 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gamma-aminobutyric acid receptor subunit alpha-6

Name:

Gamma-aminobutyric acid receptor subunit alpha-6

Synonyms:

GABA A alpha6 | GABA receptor alpha-6 subunit | GABRA6 | GBRA6_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

51029.60

Organism:

Homo sapiens (Human)

Description:

GABA A alpha6 0 HUMAN::Q16445

Residue:

453

Sequence:

MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT
DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRN
GKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP
KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM
GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA
TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEI
VLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY
SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE

BDBM50049736

n/a

Name

BDBM50049736

Synonyms:

8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid tert-butyl ester | 8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid tert-butyl ester(RY 24) | CHEMBL58757

Type

Small organic molecule

Emp. Form.

C19H19N3O3

Mol. Mass.

337.3725

SMILES

CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C

Structure