| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor 3 |
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| Ligand | BDBM50107595 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_539473 (CHEMBL1028969) |
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| Ki | 1890±n/a nM |
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| Citation |  Butini, S; Pickering, DS; Morelli, E; Coccone, SS; Trotta, F; De Angelis, M; Guarino, E; Fiorini, I; Campiani, G; Novellino, E; Schousboe, A; Christensen, JK; Gemma, S 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators. J Med Chem51:6614-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor 3 |
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| Name: | Glutamate receptor 3 |
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| Synonyms: | GRIA3_RAT | Glur3 | Glutamate receptor 3 | Glutamate receptor ionotropic, AMPA 3 | Glutamate-AMPA | Gria3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 100383.57 |
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| Organism: | RAT |
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| Description: | Glutamate-AMPA GRIA3 RAT::P19492 |
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| Residue: | 888 |
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| Sequence: | MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTE
KPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVT
PSFPTDADVQFVIQMRPALKGAILSLLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNW
QVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYM
LANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYT
SALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGM
TGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIV
VTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPE
TKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS
FLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIF
NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE
SAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVR
KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLN
EQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEF
CYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
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| BDBM50107595 |
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| n/a |
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| Name | BDBM50107595 |
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| Synonyms: | (S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cyclopenta[d]-pyrimidin-2,4(1H,3H)dione | (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID | 2-Amino-3-(2,4-dioxo-2,3,4,5,6,7-hexahydro-cyclopentapyrimidin-1-yl)-propionic acid | CHEMBL337577 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H13N3O4 |
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| Mol. Mass. | 239.2279 |
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| SMILES | N[C@@H](Cn1c2CCCc2c(=O)[nH]c1=O)C(O)=O |r| |
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| Structure | 
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