| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50275774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_493256 (CHEMBL948486) |
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| IC50 | 6000±n/a nM |
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| Citation |  Dyck, B; Tamiya, J; Jovic, F; Pick, RR; Bradbury, MJ; O'Brien, J; Wen, J; Johns, M; Madan, A; Fleck, BA; Foster, AC; Li, B; Zhang, M; Tran, JA; Vickers, T; Grey, J; Saunders, J; Chen, C Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. J Med Chem51:7265-72 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50275774 |
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| n/a |
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| Name | BDBM50275774 |
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| Synonyms: | CHEMBL512851 | N,N-Diallyl (1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropanecarbamide |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20N2OS |
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| Mol. Mass. | 276.397 |
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| SMILES | NC[C@@H]1C[C@@]1(C(=O)N(CC=C)CC=C)c1cccs1 |r| |
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| Structure | 
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