Reaction Details |
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Target | Sodium-dependent noradrenaline transporter |
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Ligand | BDBM50259342 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_500244 (CHEMBL966882) |
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IC50 | 110±n/a nM |
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Citation | Vu, AT; Cohn, ST; Terefenko, EA; Moore, WJ; Zhang, P; Mahaney, PE; Trybulski, EJ; Goljer, I; Dooley, R; Bray, JA; Johnston, GH; Leiter, J; Deecher, DC 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors. Bioorg Med Chem Lett19:2464-7 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent noradrenaline transporter |
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Name: | Sodium-dependent noradrenaline transporter |
Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 69337.72 |
Organism: | Homo sapiens (Human) |
Description: | P23975 |
Residue: | 617 |
Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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BDBM50259342 |
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n/a |
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Name | BDBM50259342 |
Synonyms: | (R,S/S,R)-syn-1-(4-chlorophenyl)-1-(methyl(phenyl)amino)-3-(methylamino)propan-2-ol | CHEMBL467324 |
Type | Small organic molecule |
Emp. Form. | C17H21ClN2O |
Mol. Mass. | 304.814 |
SMILES | CNC[C@@H](O)[C@@H](N(C)c1ccccc1)c1ccc(Cl)cc1 |r| |
Structure |
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