| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM25737 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_580036 (CHEMBL1053986) |
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| IC50 | 7±n/a nM |
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| Citation |  Shen, HC; Ding, FX; Wang, S; Deng, Q; Zhang, X; Chen, Y; Zhou, G; Xu, S; Chen, HS; Tong, X; Tong, V; Mitra, K; Kumar, S; Tsai, C; Stevenson, AS; Pai, LY; Alonso-Galicia, M; Chen, X; Soisson, SM; Roy, S; Zhang, B; Tata, JR; Berger, JP; Colletti, SL Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement. J Med Chem52:5009-12 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 62512.06 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P34914 |
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| Residue: | 554 |
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| Sequence: | MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITF
SQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTC
IVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYV
TVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPF
MPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHK
ATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLG
RKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKW
LQTEVQNPSVTSKI
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| BDBM25737 |
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| n/a |
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| Name | BDBM25737 |
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| Synonyms: | 12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid | CHEMBL215387 | US10383835, Compound 700 | Urea-based compound, 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H40N2O3 |
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| Mol. Mass. | 392.5753 |
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| SMILES | OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:25:20:27:24.23.26,25:24:20.21.19:27,THB:23:22:19:24.25.26,23:24:19:22.21.27| |
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| Structure | 
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