Reaction Details | |||
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Target | Insulin receptor | ||
Ligand | BDBM50296348 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_581975 (CHEMBL1058955) | ||
IC50 | 140±n/a nM | ||
Citation | Li, R; Pourpak, A; Morris, SW Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem52:4981-5004 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Insulin receptor | |||
Name: | Insulin receptor | ||
Synonyms: | CD_antigen=CD220 | INSR_MOUSE | IR | Insr | Insulin receptor subunit alpha | Insulin receptor subunit beta | ||
Type: | PROTEIN | ||
Mol. Mass.: | 155593.32 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_305383 | ||
Residue: | 1372 | ||
Sequence: |
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BDBM50296348 | |||
n/a | |||
Name | BDBM50296348 | ||
Synonyms: | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | CHEMBL551064 | NVP-AEW541 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H27N5O | ||
Mol. Mass. | 425.5255 | ||
SMILES | Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@@H](C1)N1CCC1 |r,wU:26.32,wD:24.27,(12.58,1.25,;12.59,-.29,;11.26,-1.07,;11.26,-2.61,;12.59,-3.38,;13.92,-2.61,;15.4,-3.09,;16.31,-1.83,;15.4,-.58,;15.87,.89,;14.85,2.02,;15.32,3.49,;16.83,3.81,;17.87,2.67,;19.37,2.99,;20.4,1.84,;21.91,2.16,;22.94,1.01,;24.44,1.33,;24.92,2.8,;23.88,3.95,;22.38,3.62,;17.39,1.2,;13.92,-1.06,;15.87,-4.56,;15.17,-5.92,;16.54,-6.63,;17.25,-5.26,;17.01,-8.1,;16.3,-9.45,;17.67,-10.16,;18.37,-8.79,)| | ||
Structure |