| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 3A |
|---|
| Ligand | BDBM50258292 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_592418 (CHEMBL1037804) |
|---|
| Ki | 11.7±n/a nM |
|---|
| Citation |  Butini, S; Budriesi, R; Hamon, M; Morelli, E; Gemma, S; Brindisi, M; Borrelli, G; Novellino, E; Fiorini, I; Ioan, P; Chiarini, A; Cagnotto, A; Mennini, T; Fracasso, C; Caccia, S; Campiani, G Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. J Med Chem52:6946-50 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 3A |
|---|
| Name: | 5-hydroxytryptamine receptor 3A |
|---|
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 55428.70 |
|---|
| Organism: | RAT |
|---|
| Description: | 5-HT3 HTR3A RAT::P35563 |
|---|
| Residue: | 483 |
|---|
| Sequence: | MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDW
RKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSI
WVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFY
VVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTL
PATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLL
CLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAV
RGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW
HYS
|
|
|
|---|
| BDBM50258292 |
|---|
| n/a |
|---|
| Name | BDBM50258292 |
|---|
| Synonyms: | 2-(4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)piperazin-1-yl)acetic acid | CHEMBL523497 | [4-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)piperazin-1-yl]acetic Acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H17FN4O2 |
|---|
| Mol. Mass. | 328.3409 |
|---|
| SMILES | OC(=O)CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
