| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2B |
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| Ligand | BDBM50302224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599590 (CHEMBL1040202) |
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| Ki | 165±n/a nM |
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| Citation |  Rotella, DP; McFarlane, GR; Greenfield, A; Grosanu, C; Robichaud, AJ; Denny, RA; Feenstra, RW; Núñez-García, S; Reinders, JH; Neut, Mv; McCreary, A; Kruse, CG; Sullivan, K; Pruthi, F; Lai, M; Zhang, J; Kowal, DM; Carrick, T; Grauer, SM; Navarra, RL; Graf, R; Brennan, J; Marquis, KL; Pausch, MH Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia. Bioorg Med Chem Lett19:5552-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2B |
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| Name: | 5-hydroxytryptamine receptor 2B |
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| Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 54312.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
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| Residue: | 481 |
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| Sequence: | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V
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| BDBM50302224 |
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| n/a |
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| Name | BDBM50302224 |
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| Synonyms: | 7-((1R,4R)-5-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)benzo[d]oxazol-2(3H)-one | 7-((1R,4R)-5-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)benzo[d]oxazol-2(3H)-one hydrobromide | CHEMBL566356 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25FN4O2 |
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| Mol. Mass. | 432.49 |
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| SMILES | Fc1ccc2[nH]c3CCC(CN4C[C@H]5C[C@@H]4CN5c4cccc5[nH]c(=O)oc45)Cc3c2c1 |r| |
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| Structure | 
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