Reaction Details |
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Target | Sodium- and chloride-dependent glycine transporter 2 |
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Ligand | BDBM50322438 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_643223 (CHEMBL1177034) |
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EC50 | >30000±n/a nM |
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Citation | Pinard, E; Alanine, A; Alberati, D; Bender, M; Borroni, E; Bourdeaux, P; Brom, V; Burner, S; Fischer, H; Hainzl, D; Halm, R; Hauser, N; Jolidon, S; Lengyel, J; Marty, HP; Meyer, T; Moreau, JL; Mory, R; Narquizian, R; Nettekoven, M; Norcross, RD; Puellmann, B; Schmid, P; Schmitt, S; Stalder, H; Wermuth, R; Wettstein, JG; Zimmerli, D Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia. J Med Chem53:4603-14 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent glycine transporter 2 |
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Name: | Sodium- and chloride-dependent glycine transporter 2 |
Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 87438.56 |
Organism: | Homo sapiens (Human) |
Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
Residue: | 797 |
Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
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BDBM50322438 |
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n/a |
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Name | BDBM50322438 |
Synonyms: | 4-[4-(2-Cyclopentyloxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-3-fluoro-benzonitrile | CHEMBL1173698 |
Type | Small organic molecule |
Emp. Form. | C24H26FN3O4S |
Mol. Mass. | 471.544 |
SMILES | CS(=O)(=O)c1ccc(OC2CCCC2)c(c1)C(=O)N1CCN(CC1)c1ccc(cc1F)C#N |
Structure |
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