Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50380051 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_810738 (CHEMBL2015971) | ||
| IC50 | 50±n/a nM | ||
| Citation |  Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett22:2497-502 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
| ||
| BDBM50380051 | |||
| n/a | |||
| Name | BDBM50380051 | ||
| Synonyms: | CHEMBL2012620 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28FN3O3S | ||
| Mol. Mass. | 481.582 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(CCCc2ccc(F)cc2)s1 |r,wU:7.10,wD:4.3,(22.05,-6.24,;20.51,-6.26,;19.76,-7.6,;19.72,-4.93,;18.18,-4.95,;17.39,-3.63,;15.85,-3.65,;15.1,-5,;15.89,-6.32,;17.42,-6.3,;13.57,-5.01,;12.79,-3.7,;11.25,-3.72,;10.5,-5.05,;11.28,-6.37,;12.82,-6.36,;8.96,-5.07,;8.18,-3.74,;8.2,-6.41,;6.66,-6.43,;5.75,-5.19,;4.29,-5.68,;4.3,-7.23,;3.03,-8.1,;1.64,-7.45,;.29,-8.19,;-1.02,-7.39,;-2.37,-8.13,;-3.69,-7.33,;-3.65,-5.79,;-4.97,-4.99,;-2.29,-5.05,;-.98,-5.85,;5.77,-7.69,)| | ||
| Structure | 
| ||