| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase receptor Ret |
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| Ligand | BDBM50384734 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_821003 (CHEMBL2039190) |
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| IC50 | 800±n/a nM |
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| Citation |  Albaugh, P; Fan, Y; Mi, Y; Sun, F; Adrian, F; Li, N; Jia, Y; Sarkisova, Y; Kreusch, A; Hood, T; Lu, M; Liu, G; Huang, S; Liu, Z; Loren, J; Tuntland, T; Karanewsky, DS; Seidel, HM; Molteni, V Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett3:140-145 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase receptor Ret |
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| Name: | Proto-oncogene tyrosine-protein kinase receptor Ret |
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| Synonyms: | Extracellular cell-membrane anchored RET cadherin 120 kDa fragment | Proto-oncogene c-Ret | RET_MOUSE | Ret | Soluble RET kinase fragment |
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| Type: | PROTEIN |
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| Mol. Mass.: | 123875.12 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_821003 |
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| Residue: | 1115 |
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| Sequence: | MAKATSGAAGLGLKLILLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAP
GEVPSFRLGQHLYGVYRTRLHENDWIRINETTGLLYLNQSLDHSSWEQLSIRNGGFPLLT
IFLQVFLGSTAQREGECHWPGCTRVYFSFINDTFPNCSSFKAQDLCIPETAVSFRVRENR
PPGTFYHFHMLPVQFLCPNISVKYSLLGGDSLPFRCDPDCLEVSTRWALDRELREKYVLE
ALCIVAGPGANKETVTLSFPVTVYDEDDSAPTFSGGVGTASAVVEFKRKEGTVVATLQVF
DADVVPASGELVRRYTNTLLSGDSWAQQTFRVEHSPIETLVQVNNNSVRATMHNYKLILN
RSLSISESRVLQLAVLVNDSDFQGPGAGGILVLHFNVSVLPVTLNLPRAYSFPVNKRARR
YAQIGKVCVENCQEFSGVSIQYKLQPSSINCTALGVVTSPEDTSGTLFVNDTEALRRPEC
TKLQYTVVATDRQTRRQTQASLVVTVEGTSITEEVGCPKSCAVNKRRPECEECGGLGSPT
GRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDAVESRDANICPQDCLRADIVGGHERGE
RQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDALCRTIITAALFSLIISILLSIFCVCH
HHKHGHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSTENQVPVDSFKIPEDPKWEF
PRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLL
KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSGGGSRNSSSLD
HPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV
YEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPER
LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLA
ASTPSDSLLYDDGLSEEETPLVDCNNAPLPRSLPSTWIENKLYGMSDPNWPGESPVPLTR
ADGTSTGFPRYANDSVYANWMVSPSAAKLMDTFDS
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| BDBM50384734 |
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| n/a |
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| Name | BDBM50384734 |
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| Synonyms: | CHEMBL2037211 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H29F3N6O2 |
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| Mol. Mass. | 586.6069 |
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| SMILES | CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1 |
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| Structure | 
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