| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 3 |
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| Ligand | BDBM50387664 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_830654 (CHEMBL2061589) |
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| IC50 | 13±n/a nM |
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| Citation |  Nitta, A; Iura, Y; Tomioka, H; Sato, I; Morihira, K; Kubota, H; Morokata, T; Takeuchi, M; Ohta, M; Tsukamoto, S; Imaoka, T; Takahashi, T Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists. Bioorg Med Chem Lett22:4951-4 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 3 |
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| Name: | C-C chemokine receptor type 3 |
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| Synonyms: | C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 41053.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51677 |
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| Residue: | 355 |
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| Sequence: | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
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| BDBM50387664 |
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| n/a |
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| Name | BDBM50387664 |
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| Synonyms: | CHEMBL2057766 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32F2N4O2 |
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| Mol. Mass. | 518.5975 |
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| SMILES | Fc1ccc2cc(CN3[C@@H]4CC[C@@H]3CC(C4)NC(=O)N3CCC[C@H]3C(=O)Nc3ccccc3F)ccc2c1 |r,TLB:7:8:14.15.13:10.11,16:14:8:10.11| |
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| Structure | 
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