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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50394026 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_855921 (CHEMBL2161684) | ||
| IC50 | 68±n/a nM | ||
| Citation |  Scott, JS; Gill, AL; Godfrey, L; Groombridge, SD; Rees, A; Revill, J; Schofield, P; Sörme, P; Stocker, A; Swales, JG; Whittamore, PR Optimisation of pharmacokinetic properties in a neutral series of 11ß-HSD1 inhibitors. Bioorg Med Chem Lett22:6756-61 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM50394026 | |||
| n/a | |||
| Name | BDBM50394026 | ||
| Synonyms: | CHEMBL2158479 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H29N3O2 | ||
| Mol. Mass. | 355.4739 | ||
| SMILES | Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1 |r,wU:8.7,wD:15.16,TLB:16:15:8:10.12.11,12:13:18:10.11.17,12:11:8.13.14:18,THB:7:8:18:10.11.17,17:11:8:14.15.18,17:15:8:10.12.11,(-6.22,-2.87,;-4.89,-2.1,;-4.89,-.56,;-3.56,.21,;-2.22,-.55,;-.89,.22,;-.9,1.76,;.44,-.54,;1.77,.23,;2.94,1.54,;4.28,1.07,;5.67,1.45,;4.68,.15,;3.26,.69,;3.23,2.28,;4.24,3.53,;4.23,5.07,;5.65,2.97,;2.91,3.02,;-2.22,-2.1,;-3.55,-2.88,;-.99,-3.03,;-1.01,-4.57,;.44,-5.07,;1.37,-3.84,;.49,-2.58,)| | ||
| Structure | 
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