| Reaction Details |
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 | Report a problem with these data |
| Target | Glycylpeptide N-tetradecanoyltransferase |
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| Ligand | BDBM50101969 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_862035 (CHEMBL2174064) |
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| IC50 | 51000±n/a nM |
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| Citation |  Yu, Z; Brannigan, JA; Moss, DK; Brzozowski, AM; Wilkinson, AJ; Holder, AA; Tate, EW; Leatherbarrow, RJ Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery. J Med Chem55:8879-90 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycylpeptide N-tetradecanoyltransferase |
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| Name: | Glycylpeptide N-tetradecanoyltransferase |
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| Synonyms: | Myristoyl-CoA:protein N-myristoyltransferase | NMT | NMT_PLAF7 | Peptide N-myristoyltransferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47977.09 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_862035 |
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| Residue: | 410 |
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| Sequence: | MNDDKKDFVGRDLYQLIRNAKDKIKIDYKFWYTQPVPKINDEFDENVNEPFISDNKVEDV
RKEEYKLPSGYAWCVCDITKENDRSDIYNLLTDNYVEDDDNVFRFNYSSEFLLWALSSPN
YVKNWHIGVKYESTNKLVGFISAIPIDMCVNKNIIKMAEVNFLCVHKSLRSKRLAPVLIK
EITRRINLESIWQAIYTAGVYLPKPISTARYFHRSINVKKLIEIGFSCLNTRLTMSRAIK
LYRIDDTLNIKNLRLMKKKDIDGLQKLLNEHLKQYNLHAIFSKEDVAHWFTPIDQVIYTY
VNEENGEIKDLISFYSLPSKVLGNNKYNILNAAFSFYNITTTTTFKNLIQDAICLAKRNN
FDVFNALEVMDNYSVFQDLKFGEGDGSLKYYLYNWKCASCHPSKIGIVLL
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| BDBM50101969 |
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| n/a |
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| Name | BDBM50101969 |
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| Synonyms: | 3-Methyl-4-{3-[(pyridin-3-ylmethyl)-amino]-propoxy}-benzofuran-2-carboxylic acid ethyl ester | CHEMBL301315 | Ro-09-4609 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N2O4 |
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| Mol. Mass. | 368.4263 |
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| SMILES | CCOC(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C |
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| Structure | 
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