Reaction Details |
| Report a problem with these data |
Target | Neprilysin |
---|
Ligand | BDBM50048507 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_144314 (CHEMBL754359) |
---|
IC50 | 82±n/a nM |
---|
Citation | Robl, JA; Simpkins, LM; Sulsky, R; Sieber-McMaster, E; Stevenson, J; Kelly, YF; Sun, C; Misra, RN; Ryono, DE; Asaad, MM; Bird, J; Trippodo, NC; Karanewsky, DS Dual metalloprotease inhibitors. II. Effect of substitution and stereochemistry on benzazepinone based mercaptoacetyls Bioorg Med Chem Lett4:1795-1800 (1994) Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neprilysin |
---|
Name: | Neprilysin |
Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85505.38 |
Organism: | Homo sapiens (Human) |
Description: | P08473 |
Residue: | 750 |
Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
|
|
|
BDBM50048507 |
---|
n/a |
---|
Name | BDBM50048507 |
Synonyms: | CHEMBL299169 | [(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-oxo-azepan-1-yl]-acetic acid |
Type | Small organic molecule |
Emp. Form. | C17H22N2O4S |
Mol. Mass. | 350.433 |
SMILES | OC(=O)CN1CCCC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O |
Structure |
|