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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50413236 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_493722 (CHEMBL949477) | ||
| IC50 | 8317.64±n/a nM | ||
| Citation |  Di Fabio, R; Arban, R; Bernasconi, G; Braggio, S; Blaney, FE; Capelli, AM; Castiglioni, E; Donati, D; Fazzolari, E; Ratti, E; Feriani, A; Contini, S; Gentile, G; Ghirlanda, D; Sabbatini, FM; Andreotti, D; Spada, S; Marchioro, C; Worby, A; St-Denis, Y Dihydropyrrole[2,3-d]pyridine derivatives as novel corticotropin-releasing factor-1 antagonists: mapping of the receptor binding pocket by in silico docking studies. J Med Chem51:7273-86 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50413236 | |||
| n/a | |||
| Name | BDBM50413236 | ||
| Synonyms: | CHEMBL458780 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H12F6N6OS | ||
| Mol. Mass. | 510.415 | ||
| SMILES | Cc1cc(-n2ccc(n2)-c2nccs2)c2[nH]c(=O)n(-c3ccc(cc3C(F)(F)F)C(F)(F)F)c2n1 |(21.34,-6.37,;22.68,-5.6,;22.68,-4.05,;24.01,-3.28,;24,-1.74,;22.75,-.84,;23.23,.63,;24.77,.63,;25.25,-.83,;25.68,1.87,;27.22,1.88,;27.69,3.34,;26.44,4.23,;25.19,3.34,;25.34,-4.05,;26.82,-3.57,;27.73,-4.82,;29.27,-4.82,;26.82,-6.08,;27.29,-7.53,;26.26,-8.68,;26.73,-10.14,;28.24,-10.46,;29.27,-9.31,;28.79,-7.85,;29.82,-6.7,;30.91,-5.6,;28.7,-5.65,;30.94,-7.76,;28.72,-11.93,;29.11,-13.41,;30.2,-11.49,;27.25,-12.37,;25.34,-5.6,;24.01,-6.37,)| | ||
| Structure | 
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