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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50413237 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_493722 (CHEMBL949477) | ||
| IC50 | >10000±n/a nM | ||
| Citation |  Di Fabio, R; Arban, R; Bernasconi, G; Braggio, S; Blaney, FE; Capelli, AM; Castiglioni, E; Donati, D; Fazzolari, E; Ratti, E; Feriani, A; Contini, S; Gentile, G; Ghirlanda, D; Sabbatini, FM; Andreotti, D; Spada, S; Marchioro, C; Worby, A; St-Denis, Y Dihydropyrrole[2,3-d]pyridine derivatives as novel corticotropin-releasing factor-1 antagonists: mapping of the receptor binding pocket by in silico docking studies. J Med Chem51:7273-86 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50413237 | |||
| n/a | |||
| Name | BDBM50413237 | ||
| Synonyms: | CHEMBL488592 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H14F6N6S | ||
| Mol. Mass. | 508.442 | ||
| SMILES | Cc1nc2c(cc(C)nc2n1-c1ccc(cc1C(F)(F)F)C(F)(F)F)-n1ccc(n1)-c1nccs1 |(.44,-25.52,;-1.1,-25.52,;-2.01,-24.26,;-3.48,-24.74,;-4.82,-23.98,;-6.15,-24.75,;-6.15,-26.29,;-7.48,-27.06,;-4.81,-27.06,;-3.48,-26.29,;-2.01,-26.77,;-1.53,-28.23,;-2.56,-29.38,;-2.09,-30.84,;-.58,-31.16,;.45,-30.01,;-.03,-28.55,;1,-27.4,;2.08,-26.3,;-.13,-26.35,;2.11,-28.46,;-.1,-32.62,;.29,-34.11,;1.37,-32.19,;-1.58,-33.07,;-4.82,-22.44,;-6.07,-21.54,;-5.6,-20.07,;-4.06,-20.07,;-3.58,-21.53,;-3.15,-18.82,;-1.61,-18.82,;-1.14,-17.35,;-2.39,-16.47,;-3.63,-17.36,)| | ||
| Structure | 
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