| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Ligand | BDBM50348363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_757614 (CHEMBL1804871) |
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| IC50 | 250±n/a nM |
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| Citation |  Gage, JL; Onrust, R; Johnston, D; Osnowski, A; Macdonald, W; Mitchell, L; Urögdi, L; Rohde, A; Harbol, K; Gragerov, S; Dormán, G; Wheeler, T; Florio, V; Cutshall, NS N-Acylhydrazones as inhibitors of PDE10A. Bioorg Med Chem Lett21:4155-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Synonyms: | PDE10_MOUSE | Pde10a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 89407.64 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1458264 |
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| Residue: | 790 |
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| Sequence: | MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKD
EPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYF
LGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRG
TGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQ
VQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN
KELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV
DLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN
MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMW
PGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNG
LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVI
GLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQ
LGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKST
PEKLNVKVED
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| BDBM50348363 |
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| n/a |
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| Name | BDBM50348363 |
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| Synonyms: | CHEMBL1800826 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18F3N3O2S |
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| Mol. Mass. | 433.447 |
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| SMILES | COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1C(F)(F)F |
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| Structure | 
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