Reaction Details |
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Target | Muscarinic acetylcholine receptor M5 |
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Ligand | BDBM50263887 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_937326 (CHEMBL2319089) |
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IC50 | 3970±n/a nM |
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Citation | Sheffler, DJ; Sevel, C; Le, U; Lovell, KM; Tarr, JC; Carrington, SJ; Cho, HP; Digby, GJ; Niswender, CM; Conn, PJ; Hopkins, CR; Wood, MR; Lindsley, CW Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism. Bioorg Med Chem Lett23:223-7 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M5 |
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Name: | Muscarinic acetylcholine receptor M5 |
Synonyms: | ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 60161.80 |
Organism: | RAT |
Description: | Cholinergic, muscarinic M5 CHRM5 RAT::P08911 |
Residue: | 531 |
Sequence: | MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQL
KTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNL
LVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPD
ECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKK
REPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVT
TCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKY
FLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPN
LSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGY
WLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
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BDBM50263887 |
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n/a |
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Name | BDBM50263887 |
Synonyms: | 1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | 1-(1'-2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | CHEMBL522460 |
Type | Small organic molecule |
Emp. Form. | C25H32N4O |
Mol. Mass. | 404.5478 |
SMILES | Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O |
Structure |
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