Reaction Details |
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Target | Rap guanine nucleotide exchange factor 4 |
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Ligand | BDBM50425528 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_936073 (CHEMBL2319315) |
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IC50 | 3800±n/a nM |
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Citation | Chen, H; Tsalkova, T; Chepurny, OG; Mei, FC; Holz, GG; Cheng, X; Zhou, J Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem56:952-62 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Rap guanine nucleotide exchange factor 4 |
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Name: | Rap guanine nucleotide exchange factor 4 |
Synonyms: | CGEF2 | EPAC 2 | EPAC2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RAPGEF4 | RPGF4_HUMAN | cAMP-GEFII | cAMP-regulated guanine nucleotide exchange factor II |
Type: | PROTEIN |
Mol. Mass.: | 115526.83 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1504794 |
Residue: | 1011 |
Sequence: | MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
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BDBM50425528 |
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n/a |
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Name | BDBM50425528 |
Synonyms: | CHEMBL2313649 |
Type | Small organic molecule |
Emp. Form. | C16H16N2O2S |
Mol. Mass. | 300.375 |
SMILES | Cc1cc(C)c(c(C)c1)S(=O)(=O)n1ccc2ncccc12 |
Structure |
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