Reaction Details |
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Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
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Ligand | BDBM50426580 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_938948 (CHEMBL2328437) |
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IC50 | 58±n/a nM |
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Citation | Marchais-Oberwinkler, S; Xu, K; Wetzel, M; Perspicace, E; Negri, M; Meyer, A; Odermatt, A; Möller, G; Adamski, J; Hartmann, RW Structural optimization of 2,5-thiophene amides as highly potent and selective 17ß-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis. J Med Chem56:167-81 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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17-beta-hydroxysteroid dehydrogenase type 2 |
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Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
Type: | Oxidoreductase; single-pass type II membrane protein |
Mol. Mass.: | 42795.29 |
Organism: | Homo sapiens (Human) |
Description: | Enzyme was partially purified from human placenta. |
Residue: | 387 |
Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
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BDBM50426580 |
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n/a |
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Name | BDBM50426580 |
Synonyms: | CHEMBL2324690 |
Type | Small organic molecule |
Emp. Form. | C20H19NO2S |
Mol. Mass. | 337.435 |
SMILES | COc1cccc(c1)N(C)C(=O)c1ccc(s1)-c1cccc(C)c1 |
Structure |
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