Reaction Details |
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Target | RAC-gamma serine/threonine-protein kinase |
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Ligand | BDBM50427345 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_941087 (CHEMBL2330884) |
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IC50 | 24±n/a nM |
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Citation | Addie, M; Ballard, P; Buttar, D; Crafter, C; Currie, G; Davies, BR; Debreczeni, J; Dry, H; Dudley, P; Greenwood, R; Johnson, PD; Kettle, JG; Lane, C; Lamont, G; Leach, A; Luke, RW; Morris, J; Ogilvie, D; Page, K; Pass, M; Pearson, S; Ruston, L Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. J Med Chem56:2059-73 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAC-gamma serine/threonine-protein kinase |
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Name: | RAC-gamma serine/threonine-protein kinase |
Synonyms: | AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3 |
Type: | Enzyme |
Mol. Mass.: | 55769.36 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 479 |
Sequence: | MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
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BDBM50427345 |
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n/a |
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Name | BDBM50427345 |
Synonyms: | CHEMBL2325983 | US10654855, Example 4 | US11236095, Example 4 | US9492453, 4 |
Type | Small organic molecule |
Emp. Form. | C22H25ClN6O |
Mol. Mass. | 424.927 |
SMILES | NC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)NC(C1CC1)c1ccc(Cl)cc1 |
Structure |
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