Ki Summary

Reaction Details

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Target

11-beta-hydroxysteroid dehydrogenase 1

Ligand

BDBM50430143

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_942934 (CHEMBL2342883)

IC50

24±n/a nM

Citation

Udagawa, S; Sakami, S; Takemura, T; Sato, M; Arai, T; Nitta, A; Aoki, T; Kawai, K; Iwamura, T; Okazaki, S; Takahashi, T; Kaino, M Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett23:1617-21 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

11-beta-hydroxysteroid dehydrogenase 1

Name:

11-beta-hydroxysteroid dehydrogenase 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

32369.70

Organism:

Mus musculus (mouse)

Description:

P50172

Residue:

292

Sequence:

MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN

BDBM50430143

n/a

Name

BDBM50430143

Synonyms:

CHEMBL2338243

Type

Small organic molecule

Emp. Form.

C25H37N3O2

Mol. Mass.

411.5802

SMILES

CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(C3CCCCC3)c12 |r,wU:6.5,13.14,TLB:10:9:16:12.11.6,10:11:15.9.8:16,6:7:15:12.10.11,THB:6:11:15:8.7.16,5:6:15.9.8:16,(28.89,-30.97,;29.99,-32.07,;29.98,-30.52,;31.53,-32.12,;32.46,-33.35,;32.09,-34.84,;33.27,-35.83,;34.66,-35.24,;35.72,-36.47,;35.73,-38.06,;34.32,-38.64,;33.29,-37.37,;34.7,-37.7,;36.02,-37.2,;37.56,-37.18,;37.23,-38.47,;36.02,-35.71,;30.68,-35.47,;30.65,-37.02,;29.31,-34.78,;27.96,-35.53,;26.82,-34.49,;27.46,-33.08,;26.7,-31.75,;27.48,-30.43,;26.73,-29.1,;25.19,-29.09,;24.41,-30.41,;25.17,-31.75,;29,-33.26,)|

Structure