Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50430150 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_942935 (CHEMBL2342884) | ||
IC50 | 127±n/a nM | ||
Citation | Udagawa, S; Sakami, S; Takemura, T; Sato, M; Arai, T; Nitta, A; Aoki, T; Kawai, K; Iwamura, T; Okazaki, S; Takahashi, T; Kaino, M Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett23:1617-21 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50430150 | |||
n/a | |||
Name | BDBM50430150 | ||
Synonyms: | CHEMBL2338261 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H27N3O2 | ||
Mol. Mass. | 377.4794 | ||
SMILES | O[C@]12CC3CC(C1)[C@@H](C(C3)C2)N1CCCc2c(cnn2-c2ccccc2)C1=O |r,wU:7.13,1.0,TLB:9:8:2.3.4:6,THB:9:3:6:10.8.7,7:8:2:4.5.6,7:5:2:10.9.8,11:7:2.3.4:6,(30.86,-31.1,;29.32,-31.12,;30.53,-32.38,;29.03,-31.98,;29.02,-30.39,;27.97,-29.16,;29.32,-29.63,;26.57,-29.76,;26.6,-31.29,;27.62,-32.55,;28,-31.62,;25.4,-28.77,;25.77,-27.27,;24.83,-26.04,;23.3,-26,;22.31,-27.18,;22.62,-28.7,;21.27,-29.45,;20.14,-28.42,;20.78,-27.01,;20.02,-25.68,;20.8,-24.35,;20.04,-23.01,;18.5,-23,;17.72,-24.33,;18.48,-25.67,;23.99,-29.4,;23.96,-30.94,)| | ||
Structure |