| Reaction Details |
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 | Report a problem with these data |
| Target | Pyruvate kinase PKM |
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| Ligand | BDBM50434635 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_963160 (CHEMBL2390802) |
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| EC50 | 22±n/a nM |
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| Citation |  Guo, C; Linton, A; Jalaie, M; Kephart, S; Ornelas, M; Pairish, M; Greasley, S; Richardson, P; Maegley, K; Hickey, M; Li, J; Wu, X; Ji, X; Xie, Z Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators. Bioorg Med Chem Lett23:3358-63 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pyruvate kinase PKM |
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| Name: | Pyruvate kinase PKM |
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| Synonyms: | KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2) |
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| Type: | Protein |
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| Mol. Mass.: | 57944.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14618 |
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| Residue: | 531 |
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| Sequence: | MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
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| BDBM50434635 |
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| n/a |
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| Name | BDBM50434635 |
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| Synonyms: | CHEMBL2385099 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13ClN2O5S |
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| Mol. Mass. | 368.792 |
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| SMILES | COc1cccc(NS(=O)(=O)c2cc3OCC(=O)Nc3cc2Cl)c1 |
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| Structure | 
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