Reaction Details |
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Target | Ileal sodium/bile acid cotransporter |
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Ligand | BDBM50434851 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_963360 (CHEMBL2388857) |
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IC50 | 59±n/a nM |
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Citation | Wu, Y; Aquino, CJ; Cowan, DJ; Anderson, DL; Ambroso, JL; Bishop, MJ; Boros, EE; Chen, L; Cunningham, A; Dobbins, RL; Feldman, PL; Harston, LT; Kaldor, IW; Klein, R; Liang, X; McIntyre, MS; Merrill, CL; Patterson, KM; Prescott, JS; Ray, JS; Roller, SG; Yao, X; Young, A; Yuen, J; Collins, JL Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem56:5094-114 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ileal sodium/bile acid cotransporter |
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Name: | Ileal sodium/bile acid cotransporter |
Synonyms: | ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal bile acid transporter | Ileal bile acid transporter/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2 | NTCP2_HUMAN | SLC10A2 |
Type: | Enzyme |
Mol. Mass.: | 37714.89 |
Organism: | Homo sapiens (Human) |
Description: | SLC10A2 |
Residue: | 348 |
Sequence: | MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLG
HIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVD
GDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSL
GFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAF
AAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
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BDBM50434851 |
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n/a |
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Name | BDBM50434851 |
Synonyms: | CHEMBL2387419 | US9040518, 52 |
Type | Small organic molecule |
Emp. Form. | C26H36N2O6S |
Mol. Mass. | 504.639 |
SMILES | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CN[C@@H](CO)C(O)=O)c(OC)cc2[C@H](N1)c1ccccc1 |r| |
Structure |
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