Reaction Details |
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Target | Serine/threonine-protein kinase PAK 1 |
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Ligand | BDBM50437038 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_971749 (CHEMBL2404585) |
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IC50 | 957±n/a nM |
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Citation | Xu, Y; Foulks, JM; Clifford, A; Brenning, B; Lai, S; Luo, B; Parnell, KM; Merx, S; McCullar, MV; Kanner, SB; Ho, KK Synthesis and structure-activity relationship of 2-arylamino-4-aryl-pyrimidines as potent PAK1 inhibitors. Bioorg Med Chem Lett23:4072-5 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase PAK 1 |
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Name: | Serine/threonine-protein kinase PAK 1 |
Synonyms: | 2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK |
Type: | n/a |
Mol. Mass.: | 60640.15 |
Organism: | Homo sapiens (Human) |
Description: | Q13153 |
Residue: | 545 |
Sequence: | MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
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BDBM50437038 |
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n/a |
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Name | BDBM50437038 |
Synonyms: | CHEMBL2403067 |
Type | Small organic molecule |
Emp. Form. | C25H27ClN6O |
Mol. Mass. | 462.974 |
SMILES | CCOc1cc(Nc2ncc(Cl)c(n2)-c2cccc(CC#N)c2)ccc1N1CCN(C)CC1 |
Structure |
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