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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Insulin-like growth factor 1 receptor | ||
| Ligand | BDBM50437362 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_972567 (CHEMBL2410389) | ||
| IC50 | 9.0±n/a nM | ||
| Citation |  Jin, M; Petronella, BA; Cooke, A; Kadalbajoo, M; Siu, KW; Kleinberg, A; May, EW; Gokhale, PC; Schulz, R; Kahler, J; Bittner, MA; Foreman, K; Pachter, JA; Wild, R; Epstein, D; Mulvihill, MJ Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics. ACS Med Chem Lett4:627-31 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Insulin-like growth factor 1 receptor | |||
| Name: | Insulin-like growth factor 1 receptor | ||
| Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
| Type: | Protein | ||
| Mol. Mass.: | 154776.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08069 | ||
| Residue: | 1367 | ||
| Sequence: |
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| BDBM50437362 | |||
| n/a | |||
| Name | BDBM50437362 | ||
| Synonyms: | CHEMBL3037920 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H32FN7O | ||
| Mol. Mass. | 537.6305 | ||
| SMILES | COc1cc(nc2c(F)c(ccc12)-c1nc([C@@H]2C[C@@H](C2)N2CCN(C)CC2)n2ccnc(N)c12)-c1ccccc1 |r,wU:16.17,18.22,(3.57,-35.88,;3.58,-37.43,;4.91,-38.2,;6.24,-37.43,;7.58,-38.19,;7.58,-39.74,;6.24,-40.51,;6.25,-42.05,;7.59,-42.81,;4.92,-42.82,;3.58,-42.06,;3.58,-40.51,;4.91,-39.74,;4.93,-44.37,;6.18,-45.27,;5.71,-46.73,;6.63,-47.98,;6.39,-49.5,;7.91,-49.73,;8.15,-48.21,;8.82,-50.97,;8.2,-52.38,;9.1,-53.62,;10.64,-53.46,;11.54,-54.7,;11.26,-52.05,;10.35,-50.79,;4.17,-46.74,;3.15,-47.89,;1.65,-47.56,;1.17,-46.1,;2.2,-44.96,;1.73,-43.5,;3.7,-45.28,;8.9,-37.42,;10.24,-38.19,;11.57,-37.41,;11.57,-35.87,;10.22,-35.1,;8.9,-35.88,)| | ||
| Structure | 
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