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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Insulin-like growth factor 1 receptor | ||
| Ligand | BDBM50437363 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_972567 (CHEMBL2410389) | ||
| IC50 | 195±n/a nM | ||
| Citation |  Jin, M; Petronella, BA; Cooke, A; Kadalbajoo, M; Siu, KW; Kleinberg, A; May, EW; Gokhale, PC; Schulz, R; Kahler, J; Bittner, MA; Foreman, K; Pachter, JA; Wild, R; Epstein, D; Mulvihill, MJ Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics. ACS Med Chem Lett4:627-31 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Insulin-like growth factor 1 receptor | |||
| Name: | Insulin-like growth factor 1 receptor | ||
| Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
| Type: | Protein | ||
| Mol. Mass.: | 154776.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08069 | ||
| Residue: | 1367 | ||
| Sequence: |
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| BDBM50437363 | |||
| n/a | |||
| Name | BDBM50437363 | ||
| Synonyms: | CHEMBL3037919 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C36H35N7O | ||
| Mol. Mass. | 581.7094 | ||
| SMILES | CN1CCN(CC1)[C@H]1C[C@H](C1)c1nc(-c2ccc3c(Oc4ccccc4)cc(nc3c2)-c2ccccc2)c2c(N)nccn12 |r,wU:9.12,7.7,(67.57,-36.98,;66.66,-35.74,;65.13,-35.9,;64.22,-34.66,;64.85,-33.25,;66.38,-33.07,;67.29,-34.33,;63.94,-32.01,;62.42,-31.78,;62.65,-30.26,;64.18,-30.49,;61.74,-29.01,;62.21,-27.55,;60.96,-26.65,;60.95,-25.1,;59.6,-24.34,;59.6,-22.79,;60.93,-22.02,;60.94,-20.48,;59.6,-19.71,;59.6,-18.16,;60.94,-17.4,;60.94,-15.86,;59.6,-15.09,;58.27,-15.86,;58.27,-17.4,;62.27,-19.71,;63.6,-20.47,;63.61,-22.02,;62.27,-22.79,;62.27,-24.33,;64.93,-19.7,;66.27,-20.47,;67.6,-19.69,;67.59,-18.15,;66.25,-17.38,;64.92,-18.16,;59.72,-27.56,;58.23,-27.24,;57.75,-25.78,;57.2,-28.38,;57.67,-29.84,;59.18,-30.17,;60.2,-29.02,)| | ||
| Structure | 
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