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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium- and chloride-dependent glycine transporter 1 | ||
| Ligand | BDBM50439754 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_980599 (CHEMBL2423116) | ||
| IC50 | 20000±n/a nM | ||
| Citation |  Sugane, T; Tobe, T; Hamaguchi, W; Shimada, I; Maeno, K; Miyata, J; Suzuki, T; Kimizuka, T; Sakamoto, S; Tsukamoto, S Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors. J Med Chem56:5744-56 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium- and chloride-dependent glycine transporter 1 | |||
| Name: | Sodium- and chloride-dependent glycine transporter 1 | ||
| Synonyms: | GlyT-1 | GlyT1 | Glycine transporter 1 | SC6A9_RAT | Slc6a9 | Sodium- and chloride-dependent glycine transporter 1 | Solute carrier family 6 member 9 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 71066.17 | ||
| Organism: | attus norvegicus (Rat) | ||
| Description: | Glycine-1-transporter 0 HUMAN::P28572 | ||
| Residue: | 638 | ||
| Sequence: |
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| BDBM50439754 | |||
| n/a | |||
| Name | BDBM50439754 | ||
| Synonyms: | CHEMBL2419440 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H19N5 | ||
| Mol. Mass. | 365.4305 | ||
| SMILES | CCc1nnc(-c2ccc(nc2)-c2ccccc2)n1-c1cccc(C#N)c1C |(17.73,-47.68,;16.46,-48.55,;15.07,-47.89,;14.59,-46.43,;13.05,-46.43,;12.58,-47.9,;11.25,-48.66,;9.92,-47.87,;8.58,-48.63,;8.57,-50.17,;9.91,-50.95,;11.24,-50.19,;7.24,-50.94,;5.91,-50.15,;4.57,-50.92,;4.56,-52.46,;5.9,-53.23,;7.23,-52.47,;13.83,-48.8,;13.83,-50.34,;12.5,-51.11,;12.5,-52.65,;13.84,-53.42,;15.17,-52.65,;16.51,-53.42,;17.84,-54.17,;15.17,-51.1,;16.5,-50.33,)| | ||
| Structure | 
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