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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium- and chloride-dependent glycine transporter 2 | ||
| Ligand | BDBM50439749 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_980598 (CHEMBL2423115) | ||
| IC50 | 890±n/a nM | ||
| Citation |  Sugane, T; Tobe, T; Hamaguchi, W; Shimada, I; Maeno, K; Miyata, J; Suzuki, T; Kimizuka, T; Sakamoto, S; Tsukamoto, S Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors. J Med Chem56:5744-56 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium- and chloride-dependent glycine transporter 2 | |||
| Name: | Sodium- and chloride-dependent glycine transporter 2 | ||
| Synonyms: | Glycine transporter 2 | Glyt2 | SC6A5_RAT | Slc6a5 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 87845.43 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_980598 | ||
| Residue: | 799 | ||
| Sequence: |
| ||
| BDBM50439749 | |||
| n/a | |||
| Name | BDBM50439749 | ||
| Synonyms: | CHEMBL2417571 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17FN4 | ||
| Mol. Mass. | 344.3849 | ||
| SMILES | CCc1nnc(-c2ccc(cn2)-c2ccccc2)n1-c1ccccc1F |(17.93,-34.77,;16.62,-35.57,;15.27,-34.84,;14.79,-33.37,;13.25,-33.38,;12.77,-34.84,;11.44,-35.6,;10.12,-34.82,;8.78,-35.58,;8.77,-37.12,;10.1,-37.9,;11.44,-37.14,;7.43,-37.88,;6.1,-37.1,;4.76,-37.86,;4.76,-39.41,;6.09,-40.18,;7.43,-39.42,;14.02,-35.75,;14.03,-37.29,;12.7,-38.06,;12.7,-39.6,;14.03,-40.37,;15.37,-39.6,;15.36,-38.05,;16.69,-37.27,)| | ||
| Structure | 
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