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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium- and chloride-dependent glycine transporter 1 | ||
| Ligand | BDBM50439755 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_980599 (CHEMBL2423116) | ||
| IC50 | 800±n/a nM | ||
| Citation |  Sugane, T; Tobe, T; Hamaguchi, W; Shimada, I; Maeno, K; Miyata, J; Suzuki, T; Kimizuka, T; Sakamoto, S; Tsukamoto, S Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors. J Med Chem56:5744-56 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium- and chloride-dependent glycine transporter 1 | |||
| Name: | Sodium- and chloride-dependent glycine transporter 1 | ||
| Synonyms: | GlyT-1 | GlyT1 | Glycine transporter 1 | SC6A9_RAT | Slc6a9 | Sodium- and chloride-dependent glycine transporter 1 | Solute carrier family 6 member 9 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 71066.17 | ||
| Organism: | attus norvegicus (Rat) | ||
| Description: | Glycine-1-transporter 0 HUMAN::P28572 | ||
| Residue: | 638 | ||
| Sequence: |
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| BDBM50439755 | |||
| n/a | |||
| Name | BDBM50439755 | ||
| Synonyms: | CHEMBL2419438 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H20N4O2 | ||
| Mol. Mass. | 384.4305 | ||
| SMILES | CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(c1C)[N+]([O-])=O |(33.7,-35.11,;32.43,-35.98,;31.05,-35.32,;30.57,-33.85,;29.03,-33.86,;28.55,-35.32,;27.22,-36.08,;25.89,-35.3,;24.56,-36.06,;24.55,-37.6,;25.88,-38.38,;27.22,-37.62,;23.21,-38.36,;21.88,-37.58,;20.54,-38.35,;20.54,-39.89,;21.87,-40.66,;23.21,-39.9,;29.8,-36.23,;29.81,-37.77,;28.48,-38.54,;28.48,-40.08,;29.81,-40.85,;31.15,-40.08,;31.14,-38.53,;32.47,-37.75,;32.48,-40.84,;32.49,-42.38,;33.81,-40.08,)| | ||
| Structure | 
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