| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
|---|
| Ligand | BDBM48009 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1276663 (CHEMBL3089095) |
|---|
| IC50 | 23±n/a nM |
|---|
| Citation |  Yang, S; Li, X; Hu, F; Li, Y; Yang, Y; Yan, J; Kuang, C; Yang, Q Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem56:8321-31 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Indoleamine 2,3-dioxygenase 1 |
|---|
| Name: | Indoleamine 2,3-dioxygenase 1 |
|---|
| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45330.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14902 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
|
|
|
|---|
| BDBM48009 |
|---|
| n/a |
|---|
| Name | BDBM48009 |
|---|
| Synonyms: | 8-fluoranylindolo[2,1-b]quinazoline-6,12-dione | 8-fluoroindolo[2,1-b]quinazoline-6,12-dione | 8-fluoroindolo[2,1-b]quinazoline-6,12-quinone | MLS001216278 | SMR000544298 | US10669273, Compound 5c | cid_478574 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H7FN2O2 |
|---|
| Mol. Mass. | 266.2267 |
|---|
| SMILES | Fc1ccc-2c(c1)C(=O)c1nc3ccccc3c(=O)n-21 |
|---|
| Structure | 
|
|---|
Search and Browse
