| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin D2 receptor 2 |
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| Ligand | BDBM50444226 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1277908 (CHEMBL3094752) |
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| IC50 | 97±n/a nM |
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| Citation |  Nishikawa-Shimono, R; Sekiguchi, Y; Koami, T; Kawamura, M; Wakasugi, D; Watanabe, K; Wakahara, S; Kimura, K; Yamanobe, S; Takayama, T Isoquinoline derivatives as potent CRTH2 antagonists: design, synthesis and SAR. Bioorg Med Chem21:7674-85 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin D2 receptor 2 |
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| Name: | Prostaglandin D2 receptor 2 |
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| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 43295.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Y4 |
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| Residue: | 395 |
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| Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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| BDBM50444226 |
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| n/a |
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| Name | BDBM50444226 |
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| Synonyms: | CHEMBL3093604 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H30N2O4 |
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| Mol. Mass. | 482.5702 |
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| SMILES | OC(=O)Cc1cnc(C(=O)c2ccc(NC(=O)CC34CC5CC(CC(C5)C3)C4)cc2)c2ccccc12 |TLB:21:22:26:20.25.19,THB:23:22:25.24.26:19| |
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| Structure | 
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