Reaction Details |
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Target | Sortilin |
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Ligand | BDBM50445054 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1282402 (CHEMBL3100581) |
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IC50 | 330±n/a nM |
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Citation | Schrøder, TJ; Christensen, S; Lindberg, S; Langgård, M; David, L; Maltas, PJ; Eskildsen, J; Jacobsen, J; Tagmose, L; Simonsen, KB; Biilmann Rønn, LC; de Jong, IE; Malik, IJ; Karlsson, JJ; Bundgaard, C; Egebjerg, J; Stavenhagen, JB; Strandbygård, D; Thirup, S; Andersen, JL; Uppalanchi, S; Pervaram, S; Kasturi, SP; Eradi, P; Sakumudi, DR; Watson, SP The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett24:177-80 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sortilin |
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Name: | Sortilin |
Synonyms: | Neurotensin receptor 3 | SORT1 | SORT_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 92054.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1282402 |
Residue: | 831 |
Sequence: | MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGL
RAAAAGGAFPRGGRWRRSAPGEDEECGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDS
TGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSG
KVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLW
VSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIG
VKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDM
VFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLS
EDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLS
EPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHS
SRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSY
TIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVT
KQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPG
DKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKK
YVCGGRFLVHRYSVLQQHAEANGVDGVDALDTASHTNKSGYHDDSDEDLLE
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BDBM50445054 |
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n/a |
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Name | BDBM50445054 |
Synonyms: | CHEMBL3098745 | US10195186, Example 1 | US9682967, 1 |
Type | Small organic molecule |
Emp. Form. | C15H11F3N2O3 |
Mol. Mass. | 324.2546 |
SMILES | Cc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1 |
Structure |
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