| Reaction Details |
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 | Report a problem with these data |
| Target | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Ligand | BDBM50445547 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1285219 (CHEMBL3107150) |
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| IC50 | 271±n/a nM |
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| Citation |  Duveau, DY; Yasgar, A; Wang, Y; Hu, X; Kouznetsova, J; Brimacombe, KR; Jadhav, A; Simeonov, A; Thomas, CJ; Maloney, DJ Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors. Bioorg Med Chem Lett24:630-5 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 28974.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15428 |
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| Residue: | 266 |
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| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
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| BDBM50445547 |
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| n/a |
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| Name | BDBM50445547 |
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| Synonyms: | CHEMBL3103008 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N5 |
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| Mol. Mass. | 307.3928 |
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| SMILES | Cc1cc(c(C)n1-c1cccnc1)-c1nnc2CCCCCn12 |
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| Structure | 
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