Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50445572 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1285730 (CHEMBL3107719) | ||
IC50 | 15.0±n/a nM | ||
Citation | Ye, XY; Yoon, D; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Apedo, A; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). Bioorg Med Chem Lett24:654-60 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50445572 | |||
n/a | |||
Name | BDBM50445572 | ||
Synonyms: | CHEMBL3103433 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H25FN4O | ||
Mol. Mass. | 404.4799 | ||
SMILES | O[C@H]1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1 |r,wD:1.0,TLB:17:10:7:1.2.9,0:1:7:4.5.10,THB:11:10:7:1.2.9,10:4:1:7.8.9,10:8:1:4.5.3,3:4:7:1.2.9,3:2:7:4.5.10,(31.16,-31.37,;29.88,-32.22,;28.47,-31.64,;27.13,-32.11,;27.14,-33.61,;28.46,-34.1,;29.86,-33.75,;28.85,-35.03,;27.44,-34.46,;27.43,-32.87,;25.94,-34.89,;24.6,-34.08,;23.25,-34.83,;21.76,-34.41,;20.9,-35.69,;21.86,-36.9,;23.31,-36.37,;25.93,-36.42,;27.25,-37.19,;27.24,-38.72,;25.91,-39.49,;24.57,-38.71,;24.58,-37.18,;25.9,-41.03,;24.55,-41.79,;24.54,-43.33,;25.88,-44.11,;25.88,-45.65,;27.22,-43.34,;27.23,-41.8,)| | ||
Structure |