Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50445583 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1285731 (CHEMBL3107720) | ||
IC50 | 800±n/a nM | ||
Citation | Ye, XY; Yoon, D; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Apedo, A; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). Bioorg Med Chem Lett24:654-60 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32369.70 | ||
Organism: | Mus musculus (mouse) | ||
Description: | P50172 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50445583 | |||
n/a | |||
Name | BDBM50445583 | ||
Synonyms: | CHEMBL3103430 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H25N5O | ||
Mol. Mass. | 387.4775 | ||
SMILES | OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(cc1)-c1ccncc1 |TLB:0:1:10.8.7:5,9:8:5:3.2.1,1:2:10:7.6.5,1:6:10:3.9.2,17:10:5:3.2.1,11:10:3.9.2:7.6.5,THB:9:2:10.8.7:5,17:10:3.9.2:7.6.5,11:10:5:3.2.1,(50.71,-36.68,;49.42,-37.53,;49.4,-39.07,;48,-39.41,;46.67,-38.92,;46.67,-37.43,;48.01,-36.95,;46.97,-38.19,;46.97,-39.78,;48.39,-40.35,;45.47,-40.2,;44.13,-39.4,;42.78,-40.15,;41.29,-39.73,;40.43,-41.01,;41.39,-42.23,;42.84,-41.69,;45.46,-41.74,;44.12,-42.5,;44.11,-44.03,;45.44,-44.81,;46.78,-44.04,;46.78,-42.51,;45.43,-46.35,;44.09,-47.12,;44.08,-48.66,;45.42,-49.44,;46.76,-48.67,;46.76,-47.13,)| | ||
Structure |