Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50445588 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1285730 (CHEMBL3107719) | ||
IC50 | 282±n/a nM | ||
Citation | Ye, XY; Yoon, D; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Apedo, A; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). Bioorg Med Chem Lett24:654-60 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
| ||
BDBM50445588 | |||
n/a | |||
Name | BDBM50445588 | ||
Synonyms: | CHEMBL3103442 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H28N4O | ||
Mol. Mass. | 400.516 | ||
SMILES | OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)Cc1ccc(cc1)-c1ccccc1 |TLB:0:1:10.8.7:5,9:8:5:3.2.1,1:2:10:7.6.5,1:6:10:3.9.2,17:10:5:3.2.1,11:10:3.9.2:7.6.5,THB:9:2:10.8.7:5,17:10:3.9.2:7.6.5,11:10:5:3.2.1,(31.57,-14.14,;30.28,-14.99,;30.26,-16.53,;28.85,-16.88,;27.53,-16.38,;27.52,-14.89,;28.86,-14.41,;27.82,-15.65,;27.83,-17.24,;29.25,-17.81,;26.33,-17.67,;24.98,-16.86,;23.63,-17.62,;22.14,-17.19,;21.28,-18.47,;22.24,-19.69,;23.69,-19.16,;26.32,-19.21,;27.64,-19.98,;27.62,-21.5,;28.95,-22.27,;30.28,-21.51,;30.28,-19.98,;28.96,-19.21,;31.61,-22.28,;31.6,-23.83,;32.94,-24.61,;34.28,-23.84,;34.28,-22.28,;32.95,-21.51,)| | ||
Structure |