Reaction Details |
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Target | C-X-C chemokine receptor type 3 |
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Ligand | BDBM50446642 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1290437 (CHEMBL3119548) |
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IC50 | 1.6±n/a nM |
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Citation | Nair, AG; Wong, MK; Shu, Y; Jiang, Y; Jenh, CH; Kim, SH; Yang, DY; Zeng, Q; Shao, Y; Zawacki, LG; Duo, J; McGuinness, BF; Carroll, CD; Hobbs, DW; Shih, NY; Rosenblum, SB; Kozlowski, JA IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: improved PK, hERG and metabolic profiles. Bioorg Med Chem Lett24:1085-8 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-X-C chemokine receptor type 3 |
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Name: | C-X-C chemokine receptor type 3 |
Synonyms: | AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40665.65 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 368 |
Sequence: | MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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BDBM50446642 |
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n/a |
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Name | BDBM50446642 |
Synonyms: | CHEMBL3116485 |
Type | Small organic molecule |
Emp. Form. | C24H31Cl2N11O2 |
Mol. Mass. | 576.481 |
SMILES | CC[C@H]1CN(CCN1C1CCN(CC1)C(=O)c1ccc(Cl)nc1N)c1nc(N)c(nc1Cl)-c1nnc(NC)o1 |r| |
Structure |
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