| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C theta type |
|---|
| Ligand | BDBM50324316 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1433153 (CHEMBL3387553) |
|---|
| IC50 | 77±n/a nM |
|---|
| Citation |  Shaw, D; Hollingworth, G; Soldermann, N; Sprague, E; Schuler, W; Vangrevelinghe, E; Duggan, N; Thomas, M; Kosaka, T; Waters, N; van Eis, MJ Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Bioorg Med Chem Lett24:4812-7 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C theta type |
|---|
| Name: | Protein kinase C theta type |
|---|
| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 81878.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). |
|---|
| Residue: | 706 |
|---|
| Sequence: | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
|
|
|
|---|
| BDBM50324316 |
|---|
| n/a |
|---|
| Name | BDBM50324316 |
|---|
| Synonyms: | CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-1,2-diamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H15N5 |
|---|
| Mol. Mass. | 265.3131 |
|---|
| SMILES | NCCNc1nc(cc2cnccc12)-c1ccncc1 |
|---|
| Structure | 
|
|---|
Search and Browse
