| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin S |
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| Ligand | BDBM50030816 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1438542 (CHEMBL3385532) |
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| IC50 | 1570±n/a nM |
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| Citation |  Jadhav, PK; Schiffler, MA; Gavardinas, K; Kim, EJ; Matthews, DP; Staszak, MA; Coffey, DS; Shaw, BW; Cassidy, KC; Brier, RA; Zhang, Y; Christie, RM; Matter, WF; Qing, K; Durbin, JD; Wang, Y; Deng, GG Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. ACS Med Chem Lett5:1138-42 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin S |
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| Name: | Cathepsin S |
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| Synonyms: | CATS_MOUSE | Cats | Ctss |
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| Type: | Enzyme |
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| Mol. Mass.: | 38476.67 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | O70370 |
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| Residue: | 340 |
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| Sequence: | MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIW
EKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSN
RTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSN
EEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLP
FGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGK
DYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
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| BDBM50030816 |
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| n/a |
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| Name | BDBM50030816 |
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| Synonyms: | CHEMBL3342550 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28BrN3O |
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| Mol. Mass. | 454.403 |
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| SMILES | Brc1ccc(cc1)C(=O)N[C@@H]1CCCc2ccc(cc12)\N=C\N1CCCCCC1 |r| |
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| Structure | 
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