| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin S |
|---|
| Ligand | BDBM50030822 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1438542 (CHEMBL3385532) |
|---|
| IC50 | 3.9±n/a nM |
|---|
| Citation |  Jadhav, PK; Schiffler, MA; Gavardinas, K; Kim, EJ; Matthews, DP; Staszak, MA; Coffey, DS; Shaw, BW; Cassidy, KC; Brier, RA; Zhang, Y; Christie, RM; Matter, WF; Qing, K; Durbin, JD; Wang, Y; Deng, GG Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. ACS Med Chem Lett5:1138-42 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin S |
|---|
| Name: | Cathepsin S |
|---|
| Synonyms: | CATS_MOUSE | Cats | Ctss |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 38476.67 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | O70370 |
|---|
| Residue: | 340 |
|---|
| Sequence: | MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIW
EKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSN
RTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSN
EEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLP
FGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGK
DYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
|
|
|
|---|
| BDBM50030822 |
|---|
| n/a |
|---|
| Name | BDBM50030822 |
|---|
| Synonyms: | CHEMBL3342554 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H31FN4O4 |
|---|
| Mol. Mass. | 482.5471 |
|---|
| SMILES | CNC(=O)O[C@H]1CCc2ccc(cc2[C@@H]1NC(=O)c1ccc(F)cc1)N1CCN(CC1)C1COC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
