Reaction Details |
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Target | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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Ligand | BDBM98898 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1437293 (CHEMBL3384796) |
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IC50 | 10600±n/a nM |
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Citation | Rzasa, RM; Frohn, MJ; Andrews, KL; Chmait, S; Chen, N; Clarine, JG; Davis, C; Eastwood, HA; Horne, DB; Hu, E; Jones, AD; Kaller, MR; Kunz, RK; Miller, S; Monenschein, H; Nguyen, T; Pickrell, AJ; Porter, A; Reichelt, A; Zhao, X; Treanor, JJ; Allen, JR Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. Bioorg Med Chem22:6570-85 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A |
Type: | Enzyme |
Mol. Mass.: | 104751.53 |
Organism: | Homo sapiens (Human) |
Description: | Q9HCR9 |
Residue: | 933 |
Sequence: | MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
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BDBM98898 |
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n/a |
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Name | BDBM98898 |
Synonyms: | US8497265, 224 |
Type | Small organic molecule |
Emp. Form. | C26H27N5O2 |
Mol. Mass. | 441.5249 |
SMILES | OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 |
Structure |
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