| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily A member 1 |
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| Ligand | BDBM50362741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1451904 (CHEMBL3363074) |
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| IC50 | 26±n/a nM |
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| Citation |  Copeland, KW; Boezio, AA; Cheung, E; Lee, J; Olivieri, P; Schenkel, LB; Wan, Q; Wang, W; Wells, MC; Youngblood, B; Gavva, NR; Lehto, SG; Geuns-Meyer, S Development of novel azabenzofuran TRPA1 antagonists as in vivo tools. Bioorg Med Chem Lett24:3464-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily A member 1 |
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| Name: | Transient receptor potential cation channel subfamily A member 1 |
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| Synonyms: | ANKTM1 | Ankyrin-like with transmembrane domains protein 1 | TRPA1 | TRPA1_HUMAN | Transformation-sensitive protein p120 | Transient receptor potential cation channel subfamily A member 1 (TRPA1) |
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| Type: | Protein |
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| Mol. Mass.: | 127514.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75762 |
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| Residue: | 1119 |
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| Sequence: | MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
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| BDBM50362741 |
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| n/a |
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| Name | BDBM50362741 |
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| Synonyms: | CHEMBL1939826 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2O3S |
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| Mol. Mass. | 380.46 |
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| SMILES | COCCCOc1cccc(c1)[C@H]1NC(=S)N=C2C1C(=O)c1ccccc21 |r,c:17| |
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| Structure | 
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