BindingDB PrimarySearch

Found 1019 hits with Last Name = 'geuns-meyer' and Initial = 's'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194684 (4-methyl-N-(2-methyl-3-4-methyl-N-(2-methyl-3-(2-(...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194688 (4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM14949 (2-aminoquinazoline 5 \| 3-(2-aminoquinazolin-6-yl)-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194668 (4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194694 (CHEMBL427233 \| N-(2,3-dihydro-1H-inden-4-yl)-4-met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM35317 (4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194691 (CHEMBL212128 \| N-(4-methyl-3-(2-(methylamino)quina...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194678 (4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194686 (1-(2-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194670 (3-(2-aminoquinazolin-6-yl)-4-chloro-N-(3-(trifluor...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194671 (4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194681 (CHEMBL215019 \| N-(4-chloro-3-(trifluoromethyl)phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194683 (CHEMBL212953 \| N-(2-(2-(diethylamino)acetamido)-5-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194690 (2-fluoro-4-methyl-5-(2-(methylamino)quinazolin-6-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194679 (3-(2-aminoquinazolin-6-yl)-4-methyl-N-(2-methyl-3-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal GST-tagged JAK3 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FR...				J Med Chem 54: 8440-50 (2011) Article DOI: 10.1021/jm200911r BindingDB Entry DOI: 10.7270/Q22N52PG
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194675 (4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194700 (5-(2-aminoquinazolin-6-yl)-2-fluoro-4-methyl-N-(3-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50194691 (CHEMBL212128 \| N-(4-methyl-3-(2-(methylamino)quina...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of p38-alpha by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50319571 (CHEMBL1084451 \| N-(4-(3-(2-((1-ethylpiperidin-4-yl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2				J Med Chem 53: 4502-10 (2010) Article DOI: 10.1021/jm100301x BindingDB Entry DOI: 10.7270/Q2T43T83
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM14948 (4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 611-26 (2007) Article DOI: 10.1021/jm061107l BindingDB Entry DOI: 10.7270/Q2MC8X8S
Amgen					More data for this Ligand-Target Pair				3D Structure (docked)
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361821 (CHEMBL1938654) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal GST-tagged JAK2 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FR...				J Med Chem 54: 8440-50 (2011) Article DOI: 10.1021/jm200911r BindingDB Entry DOI: 10.7270/Q22N52PG
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50207855 (CHEMBL245744 \| N-(3-isopropylphenyl)-4-methyl-3-(3...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 after 90 mins by HTRF assay				Bioorg Med Chem Lett 17: 2886-9 (2007) Article DOI: 10.1016/j.bmcl.2007.02.067 BindingDB Entry DOI: 10.7270/Q2445M4C
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50207856 (3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 after 90 mins by HTRF assay				Bioorg Med Chem Lett 17: 2886-9 (2007) Article DOI: 10.1016/j.bmcl.2007.02.067 BindingDB Entry DOI: 10.7270/Q2445M4C
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50207852 (3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 after 90 mins by HTRF assay				Bioorg Med Chem Lett 17: 2886-9 (2007) Article DOI: 10.1016/j.bmcl.2007.02.067 BindingDB Entry DOI: 10.7270/Q2445M4C
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50266148 (CHEMBL465793 \| N-(4-(3-(2-(methylamino)pyrimidin-4...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 (unknown origin)				Bioorg Med Chem Lett 19: 424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.056 BindingDB Entry DOI: 10.7270/Q29P31HK
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM35317 (4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM14974 (CHEMBL221484 \| N-(3-(3-(Dimethylamino)propyl)-5-(t...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 after 90 mins by HTRF assay				Bioorg Med Chem Lett 17: 2886-9 (2007) Article DOI: 10.1016/j.bmcl.2007.02.067 BindingDB Entry DOI: 10.7270/Q2445M4C
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50194668 (4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194672 (4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50194674 (4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(4-(...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM14948 (4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair				3D Structure (docked)
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM14949 (2-aminoquinazoline 5 \| 3-(2-aminoquinazolin-6-yl)-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM14951 (3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM14966 (3-(2-(6-Aminopyridin-3-yl)ethynyl)-4-methyl-N-(3-(...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM14967 (3-(2-(3H-Imidazo[4,5-b]pyridin-6-yl)ethynyl)-4-met...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM14969 (4-Methyl-3-(2-(quinolin-3-yl)ethynyl)-N-(3-(triflu...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck [245-498] (Homo sapiens (Human))	BDBM14948 (4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck [245-498] (Homo sapiens (Human))	BDBM14949 (2-aminoquinazoline 5 \| 3-(2-aminoquinazolin-6-yl)-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase Lck [245-498] (Homo sapiens (Human))	BDBM14950 (3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(3...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck [245-498] (Homo sapiens (Human))	BDBM14966 (3-(2-(6-Aminopyridin-3-yl)ethynyl)-4-methyl-N-(3-(...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck [245-498] (Homo sapiens (Human))	BDBM14967 (3-(2-(3H-Imidazo[4,5-b]pyridin-6-yl)ethynyl)-4-met...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck [245-498] (Homo sapiens (Human))	BDBM14969 (4-Methyl-3-(2-(quinolin-3-yl)ethynyl)-N-(3-(triflu...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
Amgen					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM14974 (CHEMBL221484 \| N-(3-(3-(Dimethylamino)propyl)-5-(t...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 611-26 (2007) Article DOI: 10.1021/jm061107l BindingDB Entry DOI: 10.7270/Q2MC8X8S
Amgen					More data for this Ligand-Target Pair				3D Structure (crystal)
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50266148 (CHEMBL465793 \| N-(4-(3-(2-(methylamino)pyrimidin-4...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2				J Med Chem 53: 4502-10 (2010) Article DOI: 10.1021/jm100301x BindingDB Entry DOI: 10.7270/Q2T43T83
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50319572 (CHEMBL1084452 \| N-(4-(3-(2-(2-(1-methylpyrrolidin-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2				J Med Chem 53: 4502-10 (2010) Article DOI: 10.1021/jm100301x BindingDB Entry DOI: 10.7270/Q2T43T83
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM14974 (CHEMBL221484 \| N-(3-(3-(Dimethylamino)propyl)-5-(t...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 611-26 (2007) Article DOI: 10.1021/jm061107l BindingDB Entry DOI: 10.7270/Q2MC8X8S
Amgen					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361826 (CHEMBL1938659) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal GST-tagged JAK2 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FR...				J Med Chem 54: 8440-50 (2011) Article DOI: 10.1021/jm200911r BindingDB Entry DOI: 10.7270/Q22N52PG
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50266221 (CHEMBL458023 \| N-(3-methyl-4-(3-(2-(methylamino)py...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2				Bioorg Med Chem Lett 19: 424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.056 BindingDB Entry DOI: 10.7270/Q29P31HK
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50194668 (4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Src by HTRF kinase assay				J Med Chem 49: 5671-86 (2006) Article DOI: 10.1021/jm0605482 BindingDB Entry DOI: 10.7270/Q29G5MFD
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

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